I ran an experiment with Excel 2007 with several sheets, mixing up properties.
Excel seems to save the printer property in the file, sheet by sheet. ABC.XLS originally has 2-sided set for all four of its sheets. While on sheet3 I change to 1-sided, print, save, close Excel, reopen; and Sheet3 now comes up as 1-sided, and others sheets still come up as 2-sided.
Also: before all this, if I printed entire workbook, it was all two sided, that is, sheet1 is 1 of 4, other side of it is sheet2 as 2 of 4, next sheet has sheet3 as 3 of 4 and sheet 4 is on the back of it. Now, after saving 1-sided to sheet1, printing entire workbook yields sheeet1 and sheet2 on 2 sided, sheet3 alone, then sheet4.
This is a strange seeming experiment but it covers several things at once, and I'm disinclined to test 32 or 128 permutations if someone can say what the exact procedure is. I think that you (Joe) say that it's application-controlled. In that case, if someone has the rules for Office products that would be great!